Articles Accepted

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING UV-VISIBLE SPECTROSCOPY
by Mr. AKHIL M B, 29 May 2021

A simple, accurate, precise and economical method has been developed for the simultaneous estimation of pregabalin and etoricoxib in combined dosage form by using Double point standardization method. Methanol is used as the solvent and chromogenic agent added was bromocresol green. Bromocresol green is only reactive with Pregabalin form a green colour ion pair complex. ʎ max of Pregabalin and Etoricoxib was at 618nm and 235 nm respectively. The method was found to be linear in the range of 6-22 μg/ml for Pregabalin and 4.8-17.6 μg/ml for Etoricoxib. The concentration of the drugs in pharmaceutical dosage form was determined by using Double point standardization method. Validation parameters was performed and method found to be linear, accurate, precise, rugged and robust. Since no other method was developed for estimation of pregabalin and etoricoxib in combination, this method can be used for the routine quality control of drug in combined dosage form.

Current Issue
August 2022
Quick Contact