Articles Accepted

DESIGN CONSIDERATIONS OF FILM FORMING SYSTEMS FOR TOPICAL & TRANSDERMAL DRUG DELIVERY
by Mrs. Ashwini Wani, 23 Apr 2021

Human skin is a noteworthy example of sophisticated bioengineering. The scope of using skin as a route of administering systemically active compounds has attracted significant interest. Skin’s impressive barrier function not only protects exposure to harmful agents but also constrains the diffusion of topically applied drugs onto the skin. However, there remains an apparent need to develop better and more efficient formulations to treat dermatological diseases. Many methods have been developed to overcome skin barrier function and deliver drugs to achieve a therapeutic effect at the site of action. Amongst them, Film Forming Systems (FFS) is successfully represented as a novel class of formulation approach that has been marketed for topical and transdermal delivery. Compared to conventional skin formulations, FFS-designed formulations are relatively cheaper to manufacture and easier for patients to use. Therefore, it has a greater potential of being translated into a successful formulation to improve patient outcomes. An ideal FFS would form an in-situ film-flexing with the skin and remain in intimate contact with the dermal surface for a prolonged period consequently, allowing flexible dosing to treat any diseased skin part. The mechanism, advantages, design, formulation considerations, applications, and evaluation of film-forming systems are concisely reviewed in this article.

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