Articles Accepted

Megamox Mediates Eco-friendly Synthesis of Selenium Nanoparticles for Developing Immunomodulatory, Antioxidant and Antimicrobial Activities Against both Bacteria and Mycobacterium tuberculosis
by Dr. Akhilesh Dubey, 29 Dec 2020
Co-Author(s): Ahmed A Askar,Asmaa M Abouzaid,Sally A. El-Zahaby A EL-Zahaby

The research herein includes for the first time a methodology for eco-friendly preparation of Selenium nanoparticles (SeNPs) using the broad-spectrum antibiotic, Megamox (Mega.). Characterization of SeNPs was done using; UV-Vis. spectroscopy, FTIR, XRD, DLS and TEM imaging. Additionally, the immunomodulatory, antioxidant and antimicrobial activities of both SeNPs and Mega., were checked against different strains of bacteria and fungi. TEM and DLS images showed that SeNPs are monodispersed spheres with mean diameter of 22.4 nm. FTIR analysis indicated that, the hydroxyl and nitrogen moieties in Mega. were effective for reduction plus binding manner. According to the results of the nitro blue tetrazolium reduction test, both SeNPs and Mega. showed high intracellular killing activity which confirmed their immunostimulatory effect. Antioxidant activity of SeNPs and Mega. were 90 and 82 %, respectively. SeNPs presented great activity facing multi-drug resistant bacteria and TB. SeNPs showed strong activity against multi-drug resistant bacteria and Mycobacterium tuberculosis. SeNPs are considered promising cost-effective and eco-friendly anti-bacterial and anti-fungal agents that can represent a new potential nano-platform in both medical and infectious diseases control.

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