Articles Accepted

LOW CALORIE ARTIFICIAL SWEETENERS AS ALTERNATIVE EXCIPIENTS FOR PHARMACEUTICAL DOSAGE FORM DESIGN
by Dr. PRAVIN GUPTA, 31 Jul 2020
Co-Author(s): Manish Kumar,Kashmira Gohil

Tremendous research is going on in the field of preparing low calorie diet for diabetes, obesity, hypertension, and heart disease, providing potential area for growth to the food and pharmaceutical industry. Dosage forms prepared for diabetic patients lack sucrose as its breakdown into glucose and fructose starts from the mouth itself and majority of it is digested in the small intestine. As soon as it is digested, it gives rise to blood glucose level. In order to control such glucose spikes in blood their diet is immediately shifted toward low calorie food and medications with low glycemic index. Artificial intense sweeteners e.g. acesulfame potassium, sucralose, xylitol etc. in moderate amount, intensity of sweetness and physical characteristics were approved by US Food and Drug Administration as safe. This review covers the brief description, stability conditions and pharmacokinetic analysis of artificial sugars.

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