Article Details

EVALUATION OF IN VITRO CYTOTOXIC POTENTIAL OF DIFFERENT CARMUSTINE FORMULATIONS AGAINST U-87 MG HUMAN GLIOBLASTOMA CELL LINE

Audumbar D. Malia * and Anil S. Bhanwaseb

a School of Life Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur-413 255, Maharashtra, India

b Department of Pharmaceutical Chemistry, Shikshan Prasarak Mandal's College of Pharmacy, Akluj-413 101, Solapur, Maharashtra, India

For Correspondence E-mail: maliaudu442@gmail.com

 

https://doi.org/10.53879/id.61.01.14427


ABSTRACT

Glioblastoma (GBM) is a frequent as well as violent type of brain tumor. In this research work, different carmustine formulations were prepared and screened for their cytotoxic activity against U-87 MG glioblastoma and normal human fibroblast L-929 cell lines. The flexible liposomes embedded in situ nasal gel exhibited maximum percentage of growth inhibition against U-87 MG glioblastoma cell line, and in situ nasal gel exhibited lowest percentage of growth inhibition against U-87 MG glioblastoma cell lines. Flexible liposomes embedded in situ nasal gel is observed to be safe and biocompatible against normal human fibroblast L-929 cell line. In cellular uptake study, U-87 MG cell line treated with flexible liposomes embedded in situ thermoreversible intranasal gel emitted stronger and higher intensity fluorescence. It seems that the presence of flexible liposomes embedded in situ thermoreversible nasal gel inside the tumor cells, and would be the best carmustine delivery approach for the management of GBM.

Year 2024 | Volume No. 61 | Issue No.1 | Page No. 70-76
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