Article Details

INVESTIGATION OF THE HEPATOPROTECTIVE POTENTIAL OF FRACTIONS AND PHYTOSOMAL COMPLEXES OF TELFAIRIA OCCIDENTALIS HOOK F LEAF EXTRACTS ON ALCOHOL-INDUCED HEPATOTOXICITY IN RAT MODELS

Romanus C. Omeha *, Kenneth O. Okolob, Mercy E. Ugwuezea , Chukwuemeka C Mbahc , Anthony A. Atammad, Mumuni A. Momohd, Josephat I. Ogbonnac and Lydia O. Ugorjic

a Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani – Enugu State, Nigeria

b Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Enugu State, Nigeria

c Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

d Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

For Correspondence: E-mail: romanus.omeh@esut.edu.ng

 

https://doi.org/10.53879/id.61.01.14224


ABSTRACT

The aim of this work was to evaluate the hepatoprotective potential of fractions and phytosomal complexes of Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal complexes of ethanol extract fractions were prepared by the thin film hydration technique. Hepatoprotective activities were evaluated by biochemical assays and histopathological examination of liver sections. Intoxication of animals with pure ethanol significantly (p < 0.05) elevated their liver enzyme titers, whereas co-administration with various extracts and phytosomal complexes reversed the increases. Histopathological findings revealed liver tissue protective effects of the extracts with the phytosomal complexes exhibiting greater effects (p < 0.05). Significant differences at p ≤ 0.05 were observed in the liver indices of animals treated with co-administered ethanol and extract fractions or phytosomes complexes versus the positive control group. T. occidentalis leaf extract formulated as phytosomes, therefore, has good potential of enhancing the hepatoprotective activities of the extract.

Year 2024 | Volume No. 61 | Issue No.1 | Page No. 61-69
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