Article Details

PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS

Nitu Patidara , Nadeem A. Farooquia , Darshan Jamindara,b, Dinesh K. Mishrac , Rajat Goyald, Hitesh Choprae and Rupesh K. Gautama *

a Department of Pharmaceutics, Indore Institute of Pharmacy, IIST Campus, Rau-Indore-453 331, Madhya Pradesh, India

b Department of Pharmaceutics, Madhyanchal Professional University, Bhopal – 462 044, Madhya Pradesh, India

c Department of Pharmacy, Guru Ghasidas Vishwavidalaya, Bilaspur-495 009, Chhattisgarh, India

d MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala -133 207, Haryana, India

e Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai-602 105, Tamil Nadu, India

* For Correspondence: E-mail: drrupeshgautam@gmail.com

 

https://doi.org/10.53879/id.61.02.14270


ABSTRACT

The present research work aimed at the formulation of film-coated microspheres incorporating glibenclamide drug and their evaluation for the management of diabetes mellitus (DM). Microspheres were prepared by solvent evaporation methodology by the usage of ethyl cellulose as polymer, ethanol and dichloromethane as solvents and Tween 80® as a non-ionic surfactant. The film-coated membrane was prepared by pan coating method, incorporating ethyl cellulose, isopropyl alcohol, diethyl phthalate and sodium lauryl sulfate. This film membrane was coated on microspheres with the help of a spray gun. The efficiency of entrapment of the film coated microspheres of F5* batch, among different formulations, is highest and comes out to be in the range of 76.65±0.58. The percentage yield was observed to be 73.32±0.14. Morphological studies conducted by scanning electron microscope show spherical microspheres of uniform size. In vitro drug release study conducted of the coated microspheres of glibenclamide shows the highest amount of release of 97.44% in the F5*batch. The best-fit model was determined by the highest R2 value. Further, the developed formulation helps in reduction in dose dumping, with better patient compliance, and also masks the bitter taste of the drug.

Year 2024 | Volume No. 61 | Issue No.2 | Page No. 51-56
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