Article Details

EFFECT OF SURFACTANT AND METHODS OF DRYING ON METHOTREXATE HYDROCHLORIDE LOADED CHITOSAN BEADS

Rajendra M. Kotadiyaa *

a Department of Quality Assurance, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (Charusat), Charusat Campus, Changa – 388 421, Gujarat, India

* For Correspondence: E-mail: rajendrakotadiya.ph@charusat.ac.in

 

https://doi.org/10.53879/id.60.01.12631


ABSTRACT

To get chitosan beads, an ionotropic gelation technique was used in which drug containing chitosan solution added into tripolyphosphate solution. Obtained beads were evaluated to study the effect of Span 80 and methods of drying on their properties. Air drying method resulted in shrunken beads, the oven drying method resulted in dark, brittle and cracked beads, and freeze-drying method showed adverse effect on sphericity and surface topography of the beads. Higher proportion of Span 80 in the beads showed faster release. Oven-dried beads gave delayed release compared to air- and freezedried beads. In vitro drug release data depicted t70% at 365 min with 88.17 % drug release for 12 h. Thus, formation of controlled release beads can be inferred.

Year 2023 | Volume No. 60 | Issue No.1 | Page No. 91-93
Recent Issue
Current Issue
March 2024
Quick Contact