ABSTRACT

A new, accurate, and easy-to-use UV-spectrophotometry method for analyzing favipiravir in both bulk and tablet forms has been developed. Favipiravir, an antiviral drug, is classified as a modified pyrazine analogue and is also known as 6-fluoro-3-hydroxypyrazine-2-carboxamide. The drug’s concentration was determined by measuring zero-order derivative values at a wavelength of 323 nm. A linear plot was constructed, demonstrating linearity within the concentration range of 4-20 µg mL-1, with an impressive correlation coefficient (r2) of 0.9997 for the zero-order spectrophotometry method. The method’s limits of detection (LOD) and quantification (LOQ) were determined to be 0.08 g and 0.26 g, respectively. All suggested methods were rigorously tested to make sure they met the standards set by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use. The developed spectrophotometry method for analyzing favipiravir in both bulk and tablet forms are characterized by their linearity, accuracy, precision and sensitivity.