Article Details

DESIGN, SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME NEW COUMARIN FUSED OXAZOLE DERIVATIVES

Pankaj Kumara , Rishi P. Kapoorc , Abhishek Kumara *, Soundarya M. Raia and Prashant Nayakb

a Department of Pharmaceutical Chemistry, NITTE (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Mangalore– 575 018, Karnataka, India

b Department of Pharmaceutics, NITTE (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Mangalore–575 018, Karnataka, India

c Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad –244 101, UP, India

For Correspondence: E-mail: abhi12bunty@nitte.edu.in

 

https://doi.org/10.53879/id.59.12.12710


ABSTRACT

A new series of dihydro-1, 2-oxazole coumarin derivatives (SR1-SR10) was prepared using a multi-step reaction. The syntheses of intermediates coumarinyl chalcones and final compounds were characterized by IR, Mass, and 1 H NMR spectra. The final compound’s SR1-SR10 binding mode and its inhibitor susceptibility were studied by molecular docking with the receptor DNA gyrase B (PDB code: 5L3J). It is responsible for catalyzing changes during DNA replication and validated targets for antibacterial molecules. The docking score of compounds SR1-SR10 ranges from -4.18 to -2.15 kcal mol-1. Among all these compounds, chloro-substituted dihydro isoxazole chromen-2-one (SR10) showed the best docking score with -4.18 kcal mol-1. SR10 interacted with the ATP-binding site of E. coli DNA gyrase B through a hydrogen bond with GLY77 and hydrophobic bond, charged negatives and polar interaction. SR1-SR10 antibacterial inhibitory property by tube dilution method was performed, and its minimum inhibitory concentrations (MIC) were observed. The MIC values of (SR1-SR10) range from 3.12 to 25 µg mL-1. Compounds SR3 and SR10 showed significant antibacterial activity with a MIC value of 3.12 µg mL-1

Year 2022 | Volume No. 59 | Issue No.12 | Page No. 21-30
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