Table of Contents

October  2023

  • Volume 60
  • Issue 10
  • Page Nos. 96

Editorial

CGMP AND INNOVATION – TO BE PHARMA INDUSTRY CULTURE FOR THE COMING YEARS

PAGE 5-6

Dear Reader,

Under the able youthful leadership of the IDMA National president, Dr. Viranchi Shah and his fully charged, motivated and committed colleagues, IDMA has led a hitherto not witnessed, roadshows and webinars on revised cGMP and Schedule M guidelines which was the need of the ho...

Dr. Gopakumar G. Nair

Editor

Indian Drugs

Review Article

DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS

PAGE 7-18

Cyclodextrins are water-soluble oligosaccharides formed by the action of cyclodextrin glucosyl transferase enzyme (CGTase) on the medium containing starch. Cyclodextrins are proven to be a cost-effective breakthrough in the pharmaceutical industry by formulating them with polymers and drugs to im...

Vikas S. Panwara, Lokesh Adhikaria , Mona Semaltya and Ajay Semaltya *

Original Research Articles

IN SILICO, ANTIMICROBIAL AND CYTOTOXIC STUDIES OF CARBOXAMIDE DERIVATIVES AND THEIR GREEN SYNTHESIS

PAGE 19-31

5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino) phenyl) oxazolidin-5-yl) methyl) thiophene-2-carboxamide derivatives were synthesized in a simple and efficient approach using 2-(oxiran-2-ylmethyl) isoindoline-1, 3-dione, 4-(4-aminophenyl) morpholin-3-one, and 5-chlorothiophene-2-carbonyl chloride by st...

Swathi Thumulaa,b, Venkatesan Srinivasadesikanb*, Ravi K. Kottalankab and Ramu Saminenic

DESIGN, CHARACTERIZATION AND EVALUATION OF NOVEL MUCOADHESIVE NASAL INSERTS FOR THE TREATMENT OF MIGRAINE

PAGE 32-39

Recently, nasal administration has gained more attention as a safe way for delivering the active ingredients used to treat migraines. Strategies can be implemented by changing aspects like the medicines, delivery vehicle, and other components to get around the obstacles associated with convention...

Bindiya Amina , Jobin Josea * and Lalit Kumarb, c

SOLID DISPERSION SYSTEMS OF POORLY WATER SOLUBLE DRUG FEBUXOSTAT: PREPARATION, CHARACTERIZATION AND OPTIMIZATION

PAGE 40-47

Febuxostat is a poor soluble drug used in the management of hyperuricemia and gout. The present study aims at increasing the solubility of febuxostat by solid dispersion technique with the aid of various polymers (Beta cyclodextrin, Soluplus®, HPMC E5, and Kolliphor® P 407) in various drug: car...

Mangirish N. Deshpandea , Shruti S. Dessaib and Pearl Digheb*

DEVELOPMENT AND VALIDATION OF A NOVEL HPTLC METHOD FOR QUANTITATIVE ESTIMATION OF VINCAMINE FROM CATHARANTHUS ROSEUS LINN. LEAVES EXTRACT

PAGE 48-52

Catharanthus roseus (Apocynaceae), commonly known as periwinkle, is a perennial plant that is mostly found in Southern Asia. Periwinkle is rich in indole alkaloids. This research work consists of the development and validation of one of the indole alkaloids, vincamine, by HPTLC. The chromatograph...

Christina Vijua , Sneha A. Agrawala and Aruna P. Jadhava *

HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF ALECTINIB HYDROCHLORIDE IN BULK POWDER AND CAPSULE PREPARATIONS

PAGE 53-57

The high performance thin layer chromatography method described here enables simple, accurate and precise estimation of alectinib hydrochloride content in capsule formulation. To achieve adequate separation, G60 - F254 pre-coated silica gel sheets of aluminium were used as the stationary phase. A...

Shaileshkumar K. Koradiaa *, Rushik P. Thakkara , Ashok N. Mahajana , Falgun A. Mehtaa , Priyal R. Patela and Digvijaysinh G. Ranaa

STUDY OF POST SHELF LIFE AND MARKETED TABLETS OF CARVEDILOL BY RP-HPLC

PAGE 58-63

The purpose of this work was to determine the tablet content and carry out the dissolving test of expired and non-expired tablet as well as establish a simple, selective, linear, precise, accurate and sensitive RP-HPLC technique for the analysis of carvedilol tablets. The experiment was carried o...

Rupali B. Giria *, Shailesh J. Wadhera and Tukaram M. Kalyankara

QUALITY RISK ASSESSMENT AND DESIGNED EXPERIMENTS ORIENTED SIMULTANEOUS QUANTIFICATION OF ASPIRIN AND PANTOPRAZOLE SODIUM USING DRIFTS AND UFLC-DAD METHODS

PAGE 64-76

Systematized and reliable analytical methods are always of great advantage for the quality control of new drug products. Two new analytical methods were developed and validated using the multivariate approach to quantify a unique combination of aspirin and pantoprazole sodium. In the first method...

Sagar S. Pandaa *, Ravi Kumar V.V. Beraa and Chandra Sekhar Patrob

EVALUATION OF HERBOSOL SYRUP FOR ACUTE TOXICITY

PAGE 77-82

Various diseases caused due to stress and tension lead to metabolic disorders and disturbed body functions. Herbosol is a combination of potential herbal drugs meant to balance the body’s metabolism and functions. The present study aims to evaluate the acute toxicity of polyherbal herbosol syru...

Sukeshini Lotea *, Deepak Khobragadeb, Mahendra Gundeb, Kirti Sahuc and Ashish Budhranid

Short Communications

EXTRACTION AND ISOLATION OF β-AMYRIN FROM FICUS ELASTICA

PAGE 83-86

There is a huge interest in medicinally active constituents isolated from plants. β-Amyrin is a member of the class of pentacyclic triterpenoids and it is oleanane substituted at the 3 β-position by a hydroxyl group and containing a double bond between positions 12 and 13. These triterpenoids a...

Komalatha Nakkalaa *, Vrushali Kulkarnib and Kirti S. Laddhaa

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