Table of Contents

August  2023

  • Volume 60
  • Issue 8
  • Page Nos. 108

ISSN: 0019-462X (print)

Guest Editorial

OPPORTUNITY TO INNOVATE FOR INFANTS

PAGE 5-6

Dear Reader,

Lactose intolerance is well-known for decades. Difficulty to metabolize lactose due to a genetic disorder, though exists in a large population, has not been taken too seriously. Reason being, it’s not a fatal disorder and the intolerance leads to some amount of bloating, in...

Dr D B Anantha Narayana

Editorial Advisory Board Member,

Indian Drugs

Review Article

A CONCISE OUTLINE ON INNOVATIVE PERMEATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY APPROACH

PAGE 7-14

The transdermal drug administration system represents a potent substitute for administering medications orally and is also designed to offer a substitute for hypodermic injections. Presently, three generations of penetration enhancer to permeate through skin are available 1st Generatio...

Parmita Phaugata, Manish Dhalla and Suchitra Nishala*

Original Research Articles

IN SILICO STUDIES OF SOME NEWLY DESIGNED BENZIMIDAZOLETHIAZOLIDINONE BASED ANTAGONISTS OF HUMAN ESTROGEN RECEPTOR

PAGE 15-30

Breast cancer is globally associated with majority of the women. Indeed, high estrogen levels are the most common subtype of breast cancer. Three different classes of estrogen receptor antagonists are frequently used to treat such kinds of breast cancers. Each of these interacts directly with the...

Jyoti Mongaa,b, Niladry S. Ghosha,c*, Somdutt Mujward and Isha Ranie

STATISTICAL OPTIMIZATION AND ASSESSMENT OF DIVALPROEX SODIUM EXTENDED RELEASE TABLET

PAGE 31-37

The purpose of the current experimental research was to optimize the quantities of macromolecules such as Eudragit L/100-55 and HPMC-K-100M for the development of extended release tablets of divalproex sodium, an anti-convulsant or epileptic agent used in the effective management of bipolar disor...

Raghavendra K. Gundaa *, Naga Suresh K. Jujjurua , Vijayalakshmi A.b, Prathap M.c and Koteswararao G. S. N.d

L-ASPARAGINASE ENZYME PRODUCTION FROM MARINE FUNGUS BEAUVERIA BASSIANA – STATISTICAL OPTIMIZATION

PAGE 38-44

Statistical optimization was done to enhance the production of L-asparaginase by submerged fermentation from the marine fungus Beauveria bassiana, which was isolated from sediments and corals of sea. Optimization of different process parameters for the production of L-asparaginase and validation ...

Venkata Kamala Kumari Paravastua * and G. Girija Sankarb

FORMULATION AND EVALUATION OF THERMO-RESPONSIVE OCULAR IN SITU GEL OF CIPROFLOXACIN AND OLOPATADINE HCL

PAGE 45-55

Ocular in situ gel (ISG) is a promising alternative to alleviate the shortcomings of conventional formulations due to their association with dose accuracy and effective administration with prolonged contact time. Therefore, present research aimed to develop a thermo-responsive in situ gel (TRISG)...

Darakhshan A. Shaikha * and Munira M. Mominb

HYDROXYPROPYL CELLULOSE-CARBOPOL AND HYDROXYPROPYL CELLULOSE -NOVEON COMPOSITE MOUTH DISSOLVING FILMS OF AMBROXOL HYDROCHLORIDE

PAGE 56-62

Ambroxol hydrochloride is a choice of drug in acute and chronic lung infections. In the COVID-19 situation, ambroxol played a crucial role in treating bronchitis and potentiating, the effect of antibiotics in lung infections. In the present study, a patient-friendly drug delivery system of ambrox...

Avinash B. Gangurdea , Suhas K. Khairnara * and Vinod A. Bairagia

EXTRACTION, IDENTIFICATION AND ESTIMATION OF CAFFEINE IN GREEN AND BLACK TEA SAMPLES BY A SIMPLE UV-VISIBLE SPECTROSCOPIC METHOD

PAGE 63-66

Caffeine is a widely consumed psychoactive compound present in coffee, tea, soft drinks, energy drinks, and chocolates. It is a diuretic and a central nervous system (CNS) stimulant. Apart from stimulating the CNS, it exerts beneficial effects in combination with other substances like L-theanine ...

Ravali Mudigiria and Archana Jorigeb*

UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF FAVIPIRAVIR

PAGE 67-71

A new, accurate, and easy-to-use UV-spectrophotometry method for analyzing favipiravir in both bulk and tablet forms has been developed. Favipiravir, an antiviral drug, is classified as a modified pyrazine analogue and is also known as 6-fluoro-3-hydroxypyrazine-2-carboxamide. The drug’s concen...

Rupali P. Patila , Sandip D. Firkea *, Md. Mojeeb G. Khana , Mohan G. Kalaskara and Atul A. Shirkhedkara

EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF OSELTAMIVIR PHOSPHATE, FAMCICLOVIR AND ACYCLOVIR IN PURE AND DOSAGE FORMS

PAGE 72-79

For the determination of oseltamivir phosphate (OSP), acyclovir (ACL), and famciclovir (FMV) medicines in pure form and their formulations, quick, accurate, and simple spectrophotometric procedures have been established. The procedures were relied on the formation of ion-pair complexes between th...

Nandeesha Itigimathaa , Basappa C. Yallura and Manjunatha D. Hadagalib*

FORCED DEGRADATION STUDIES FOR ETHAMBUTOL BY RP-HPLC

PAGE 80-86

Literature survey of ethambutol reveals no stability indicating analytical method being reported for estimation, either in bulk or in a pharmaceutical dosage form. Therefore, a stability indicating analytical method needed to be developed and validated. In the current research, a RP-HPLC method w...

Vidhya K. Bhusaria *, Utkarsh S. Bhosalea , Nikita K. Jagtapa and Minal R. Ghantea

ANTICANCER ACTIVITY OF VITAMIN D3–TAMOXIFEN COMBINATION MICROEMULSION ON MCF-7 BREAST CELL LINE AND ITS SYNERGISTIC EFFECT

PAGE 87-97

This study investigates the anticancer activity of a combination microemulsion of vitamin D3 and tamoxifen (TMX-VD3 ME) for a synergistic effect on the MCF-7 breast cancer cell line. The combination microemulsion was prepared by dissolving the drugs in oil, mixing the oil with a surfactant, cosur...

Krantisagar S. Morea , Bhavik Dalalb, Aruna Shankarkumarb and Padma V. Devarajana *

Short Communications

CUSTARD APPLE PEELS CONTAINING SAPONIN: ISOLATION AND FORMULATION OF HERBAL SHAMPOO

PAGE 98-100

Presently, the cosmetics sector is among the fastest-expanding sectors of the economy. Plenty of researchers have reported that natural surfactants could prominently replace synthetic surfactants considering the superiority in safety and effectiveness. This research aimed to isolate surfactants f...

Sopan N. Nangarea , Dipesh P. Gosavia , Jidnyasa R. Pantwalawalkarb and Vivekanand K. Chatapa *

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