Table of Contents

July  2023

  • Volume 60
  • Issue 7
  • Page Nos. 104

ISSN: 0019-462X (print)

Guest Editorial

IT IS TIME TO TAKE ADVANTAGE OF IN VITRO CELL BASED MODELS

PAGE 5-6

Dear Reader,

Preclinical tests are crucial for assessing the toxicity and safety of new drugs before moving on to evaluating their efficacy and immunogenicity. Animal models, as well as alternatives, have long been used to study human biology and pathology. However, animal experimentation...

T. Sudhakar Johnson

Head, Technical (Phytopharma)

Viridis BioPharma Pvt. Ltd.

Review Article

EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CHIKUNGUNYA - A REVIEW

PAGE 7-15

Chikungunya is a viral disease transmitted to humans by infected mosquitoes. Like most mosquito-borne infections, the virus can only be transmitted by blood-to-blood contact, through a mosquito bite or transfusion with infected blood. The disease is characterized by the common symptoms involving ...

Deepika Rania *, Madan Kaushikb and Ranjit Singha

Original Research Articles

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-a] PYRIMIDINE-3,5-DIONES

PAGE 16-22

The organosulphur thiazolo-pyrimidines are fused heterocyclic compounds that can be anticipated as 7-thio counterparts of the genuine purine bases such as guanine and adenine. They have attained a growing significance in the domain of drug chemistry because of their diverse pharmacological activi...

Ankush Goyala , Baljeet Kaura , Amandeep Kaura , Vivek K. Guptab and Monika Guptaa *

ORODISPERSIBLE FILM FABRICATION BY HOT MELT EXTRUSION FOR DENTAL PAIN AMELIORATION BY QUALITY BY DESIGN APPROACH

PAGE 23-32

Surgical dental procedures cause pain and inflammation leading to temporary restriction of the movement of the oral cavity. Consumption of analgesic medications in the form of tablets or dispersible tablets causes compliance issues due to the compromised movability of the mandibular joint. An Ora...

Apoorva V. Phadkea and Purnima D. Amina *

AMELIORATIVE EFFECT OF AVENA SATIVA (OAT) IN DINITROBENZENE SULPHONIC ACID INDUCED INFLAMMATORY BOWEL DISEASE IN RATS

PAGE 33-41

Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal tract disease. There is an upsurge of IBD cases worldwide and there is no gold standard therapy and the drugs used to treat IBD are having many major side effects. Thus, there is a need for a better treatment option. This st...

Bhagyabhumi P. Shaha *, Vismay N. Patelb and Samir K. Shahc

FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF ELLAGIC ACID PHYTO-VESICULAR SYSTEM FOR BIOAVAILABILITY ENHANCEMENT

PAGE 42-49

Ellagic acid is a naturally occurring chemical compound found in a variety of fruits and vegetables like blackberries, raspberries, strawberries, pomegranates and cranberries. Antioxidant, antimutagenic and anticancer effects are all included in ellagic acid. Ellagic acid, on the other hand, is p...

Varsha Rawata * and Vishal Jainb

CHEMOMETRICS OPTIMIZED GREEN LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN COMBINED TABLET FORMULATION

PAGE 50-60

Pregabalin and etoricoxib have been recently approved as a potent fixed-dose combination to treat patients with neuropathic back pain effectively. The present investigation quantified both drugs by using a liquid chromatography method using principles of analytical quality-by-design. We assessed ...

Sagar S. Pandaa *, Pratap C. Routaa and Ravi Kumar V.V. Beraa

QUANTITATIVE ESTIMATION OF 6-GINGEROL, E-GUGGULSTERONE AND Z-GUGGULSTERONE IN A FIXED DOSE COMBINATION NANOEMULGEL BY RP-HPLC

PAGE 61-69

Polyherbal formulations have proved to be efficacious for the therapeutic treatment of various diseases, However, the development of validated robust analytical methods for quantification is a major challenge. The aim of this project was to develop a simple analytical method for the quantificatio...

Anita D. Chandoa , Vivek Basudkarb, Sankalp Gharatb, Munira Mominb,c* and Tabassum Khand

FEASIBILITY OF ZEBRAFISH LARVA MODEL AS A VIABLE SUBSTITUTE TO RAT NON-EVERTED SAC MODEL FOR PERMEATION EVALUATION OF BCS III DRUGS

PAGE 70-79

The oral route is the most convenient route of drug administration. Many drugs exhibit poor oral bioavailability. BCS III drugs exhibit high solubility and present a massive challenge due to poor permeability. Different permeation enhancers viz., nonionic Cremophor® RH 40, Tween® 80 and LutrolÂ...

Bhagyashri Joshia,b and Padma V. Devarajana *

BIOASSAY GUIDED HEPATOPROTECTIVE ACTIVITY OF POLYGONATUM CIRRHIFOLIUM AGAINST ISONIAZID AND RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS

PAGE 80-87

The present investigation was performed to examine the hepatoprotective effect of the aqueous ethanolic extract of Polygonatum cirrhifolium in antitubercular drug-induced liver damage. P. cirrhifolium rhizomes were crushed, dissolved in various solvents (in order of polarity), and then tested for...

Roma Ghaia , K. Nagarajanb, Parul Groverb*, Vinay Kumara , Richa Goelc , Charanpreet Kaura and Reenu Chauhana

Short Communications

APPLICATION OF VEGETABLE OILS AS NATURAL, GREEN AND SUSTAINABLE SOLVENTS FOR EXTRACTION OF PLANT MATERIALS: STUDY OF PHYTOCHEMICAL CHARACTERIZATION AND CHEMICAL PROFILING OF VARIOUS OLEO-EXTRACTS OF GLYCYRRHIZA GLABRA

PAGE 88-92

In the last decade there is a growing interest in application of green and more friendly environment solvents in both industrial and academia sectors due to various environmental concerns. Vegetable oils has been used as effective natural non-toxic and environment-friendly solvents for extraction...

Manas Ranjan Sahooa , Ramesh R. Variera , Anitha Kumari R.a , Bala Tirupura Sundari H.a , Mageswari H.a , Bala Guru H.a and Ramesh K.a

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY

PAGE 93-95

A simple, accurate, precise and economical method has been developed for the simultaneous estimation of pregabalin and etoricoxib in combined dosage form by using double point standardization method. Methanol is used as the solvent and chromogenic agent added was bromocresol green. Bromocresol gr...

Sheeja V. Kuttya , Yellina Haribabua , Akhil M. B.a * and Nihila K.a

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