Table of Contents

June  2023

  • Volume 60
  • Issue 6
  • Page Nos. 100

ISSN: 0019-462X (print)

Editorial

OPPORTUNITIES FOR PHARMA INDUSTRY’S RESEARCH COLLABORATIONS WITH CSIR-CDRI

PAGE 5-6

Dear Reader,

Industry can look forward to work with CSIR-CDRI in this new era of dynamic leadership of CSIR, with Dr. (Mrs) N. Kalaiselvi, the new Director General of CSIR and Secretary, DSIR and Dr. (Mrs) Radha Rangarajan, Director, CDRI, Lucknow, who has recently taken charge of this pi...

Dr. Gopakumar G. Nair

Editor

Indian Drugs

Review Article

BIOANALYTICAL METHOD VALIDATION: A COMPREHENSIVE ASSESSMENT OF VARIOUS REGULATORY GUIDELINES

PAGE 7-25

Bioanalytical methods are used to analyse an analyte in a biological matrix. Bioanalytical method validation is the process of determining the suitability of the given bioanalytical methodology for providing the required analytical data. Validation of the bioanalytical methods demonstrates and en...

Anamika Singha and Tamanna Narsinghania *

Original Research Articles

BIO-INSPIRED GREEN SYNTHESIS OF NICKEL NANOPARTICLES USING STERCULIA FOETIDA LEAF EXTRACT AND ITS APPLICATION FOR REMOVAL OF TRIVALENT CHROMIUM FROM AQUEOUS SOLUTION

PAGE 26-33

In the present work, a facile, eco-friendly, and cost-effective approach is described to remove Cr3+ toxic metal ions in an aqueous solution by nickel nanoparticles (NiNPs) synthesized via a green method utilizing Sterculia foetida leaf extract. The synthesized nickel nanoparticles were character...

Usha Rani N.a *, Pavani P.a , Lakshmi Tulasi S.a and T. S. R. K. Prasad Rao P.b

FORMULATION AND DEVELOPMENT OF LONG-ACTING THERMOSENSITIVE AND MUCOADHESIVE VAGINAL GEL OF METRONIDAZOLE

PAGE 34-41

The development of an in situ metronidazole gel that is mucoadhesive and thermo sensitive was the aim of this study in the fight against bacterial vaginosis. Numerous evaluation criteria have been carried out, including mucoadhesive force, pH, viscosity, syringe capability, medication content, ge...

Azima G. Munshia , Manish Goyania and Meghraj V. Suryawanshib, c*

PHYTOCHEMICAL SCREENING, ANTIBACTERIAL, ANTIOXIDANT AND ANTIINFLAMMATORY ACTIVITY OF ACMELLA OLERACEA FLOWERS

PAGE 42-49

Acmella oleracea flowers are traditionally used to treat mouth ulcers in the rural areas of Nashik, Maharashtra, India. This research project is an effort to understand the scientific basis for the utility of A. oleracea flowers and validate it for potential antimicrobial, anti-inflammatory and a...

Nikita Sanapa and Tabassum Khanb*

OXIDATIVE DEGRADATION OF TAVABOROLE: DETERMINATION BY DERIVATIVE UV SPECTROPHOTOMETRY

PAGE 50-54

The aim of the present work was to investigate degradation behavior of tavaborole upon exposure to oxidative conditions using first order derivative UV spectrophotometric method. We have developed simple and fast analytical method that can be used as quality control tool for the determination of ...

Mrinalini C. Damlea * and Mayuri H. Suryawanshia

A SENSITIVE, ECONOMICAL BIOANALYTICAL LC-MS/MS METHOD FOR SIMULTANEOUS ANALYSIS OF IRBESARTAN AND HYDROCHLOROTHIAZIDE

PAGE 55-65

A novel bioanalytical LC-MS/MS method for irbesartan and hydrochlorothiazide has been developed using deuterated internal standards. Sample pretreatment was carried out using Strata-X Cartridge 33µm. Chromatographic separation was achieved on Chromolith® High Resolution Column, 100X4.6mm, 5µ u...

Celina Nazaretha *, Sanelly Pereiraa and Raman Bathejab

A NOVEL VALIDATED STABILITY INDICATING METHOD FOR QUANTIFICATION OF EMPAGLIFLOZIN IN BULK AND MARKETED FORMULATION BY HPTLC APPLYING EXPERIMENTAL DESIGN APPROACH

PAGE 66-75

For the purpose of analyzing empagliflozin, a stability indicating high performance thin layer chromatographic method was developed. This method was optimized using design of experiment. In order to optimize the process, independent variables such as the proportion of isopropyl alcohol in the mob...

Manojkumar K. Mundea,b*, Nilesh S. Kulkarnib, Ashim K. Sena and Dhanya B. Sena

ENCAPSULATION OF THYME OIL INTO MICROSPONGES: PREPARATION, CHARACTERIZATION AND IN VITRO EVALUATION

PAGE 76-82

Thyme essential oil (TEO) is a prominent essential oil reported to have diverse properties and biological activities including anti-inflammatory. This research aims to encapsulate TEO in prepared microsponges for the purpose of controlled drug delivery and reduce the frequency of drug administrat...

Shanti B. Mishraa*, Deeksha Singhb, Amit K. Singhb and Shradhanjali Singhc

INVESTIGATION OF SUPERFLUITY POTENTIAL OF BCS-II DRUG BY USING SOLVENT SHIFT METHOD

PAGE 83-89

This research work’s motive was to investigate the superfluity potential of the BCS-II drug (Dextromethorphan HBr) by solvent shift method to evaluate the impact of polymer gain factor on superfluity potential for the enhancement of bioavailability of orally prolonged release. To maintain the s...

Uditi Handaa,b, Anuj Malikb* and Kumar Guarvea

ACECLOFENAC LOADED FILM FORMING GELS: IN VIVO STUDY

PAGE 90-93

For arthritis, there is need of development of a drug delivery system which permits less frequent dosing by maintaining a close contact with the skin for prolonged time period, thereby improving the patient compliance, especially among elderly. Till date, film forming gels of aceclofenac for arth...

Himani Bajaja *, Mayank Yadava , Seema B. Chauhana , Anjali Sharmab, Navin C. Pantc , Vinod Singhd and Mamta F. Singhe

Short Communications

QUANTITATION OF GALLIC ACID IN ACACIA NILOTICA L. PODS BY HPTLC

PAGE 94-96

The pods of Acacia nilotica L. are traditionally used for versatile medical applications and are rich in polyphenolics and flavonoids. The pods powder is available in the market either as branded or unbranded products and it is imperative that their quality be assessed by a valid analytical metho...

Kaksha Sankhaa , Munira Mominb and Tabassum Khana *

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