Table of Contents

May  2023

  • Volume 60
  • Issue 5
  • Page Nos. 108

ISSN: 0019-462X (print)

Guest Editorial

THE GLOBAL NUTRACEUTICAL DOMAIN

PAGE 5-6

Dear Reader,

Nutraceuticals is no more a fancy word shrouded in a mysterious veil. It is a gospel truth and now a well-embraced norm, that ‘positive health’ can only be fostered by nutraceuticals – be it called supplements, ayurceuticals or herbals.

Although advocating and c...

Dr R K Sanghavi

Chairman – Nutraceutical Committee (IDMA),

Consultant - NeuroMarketing & TechnoRegulatory (Pharma & Nutra)

Review Article

CORONAVIRUS DISEASE 2019 (COVID-19): PUBLIC HEALTH EMERGENCY

PAGE 7-21

An outbreak of a respiratory sickness started in Wuhan, China in December 2019 and the causative agent was found be a novel betacoronovirus of the same subgenus as SARSCoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) quickly spread ar...

Babita Sarangia *, Jyotirmaya Sahooa , Utpal Janab and Guru P. Mohantac

Original Research Articles

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL BIS-HETERO CYCLIC DERIVATIVES

PAGE 22-28

The present research outlines a series of bis-hetero cyclic derivatives (a1-6) synthesized from methyl-1-(2, 5-dioxopyrrolidin-1-yl) -6- methyl -2- oxo -4- phenyl -1, 2, 3, 4- tetrahydro pyrimidine -5- carboxylate treated with different aromatic aldehydes under acidic environment. The synthesized...

Sathish K. Konidalaa , Govindarao Kamalab,c*, Srinivasan Nagarajanc and Durga R. Gunnad

EFFECT OF PREPARATION TEMPERATURE ON ETHYLCELLULOSE MICROSPHERE PROPERTIES PREPARED BY OIL-IN-OIL EMULSION SOLVENT EVAPORATION PROCESS

PAGE 29-41

The present study aims to formulate ethylcellulose microspheres using the oil-in-oil emulsion solvent evaporation method and judge the outcome of processing temperature on their features. The effects of the evaporation rate of the solvent on the particle properties and drug release characteristic...

Prasanta K. Mohapatraa * and Sunit K. Sahoob

SOLID LIPID NANOPARTICLES OF GABAPENTIN FOR PARTIAL SEIZURES

PAGE 42-49

The goal of this research was to create a stable formulation of gabapentin solid lipid nanoparticles which would allow it to pass across the blood-brain barrier more easily. They were prepared by solvent evaporation method. In the present investigation, beeswax and carnauba wax were used as solid...

Shital Kamathea , Nagesh C.a *, Suma N.a , Pankaj Patila and Chaitali Muchandia

PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT ACTIVITY AND FTIR SPECTROSCOPIC ANALYSIS OF RED LEAF LETTUCE AND GREEN LEAF LETTUCE (LACTUCA SATIVA L.)

PAGE 50-56

This study was conducted to analyze the phytochemical compounds, the profile of infrared spectrophotometric, total phenolic contents (TPC) and antioxidant activity of ethanol extract of red leaf lettuce (RL) and green leaf lettuce (GL). RL and GL were extracted with 70 % ethanol using the macerat...

Nastiti Utamia * and Prashinta N. Damayantib

STABILITY INDICATING ISOCRATIC HPLC APPROACH TO QUANTIFY MONTELUKAST AND BILASTINE MIX IN BULK AND TABLET FORMULATION

PAGE 57-65

This paper describes an novel, rapid, simple, meticulous and unerring “stability indicating HPLC method” for the assessment of montelukast (MTT) and bilastine (BLE) mix in existence of their degradation products in tablet formulation. Zorbax column XDB-C18 was utilized to separate and analyse...

Balaji Gupta V.L.N. Tiruveedhia, b*, Venkateswara Rao Battulab, Kishore Babu Bonigeb and Ramanjaneyulu V. V. Matlapudic

SIMULTANEOUS UV METHOD DEVELOPMENT FOR DETERMINATION OF ROTIGOTINE HYDROCHLORIDE AND RASAGILINE MESYLATE

PAGE 73-79

A precise, accurate analytical UV spectroscopic method has been developed for simultaneous estimation of rotigotine hydrochloride and rasagiline mesylate by using first order derivative spectroscopy. 50 µg mL-1 solutions of both drugs were scanned in the range of 200-800 nm and the first order o...

Shivani M. Patela * and Lalit L. Jhab

MULMINATM REVERSES MEMORY IMPAIRMENT INDUCED BY GABAPENTIN IN PTZ EPILEPTIC MOUSE MODEL AND EXHIBITS SYNERGISTIC ANTIEPILEPTIC ACTIVITY

PAGE 80-88

Epilepsy is a neurological condition that causes unprovoked, recurrent seizures and memory impairment is a common side effect of epileptic treatment. The present study was conceptualized to evaluate the protective effect of the nootropic herbal drink MulminaTM against memory impairment induced by...

Bhooshitha A. Nagesha , Sneha Desaia , Krishna K. Lingannaa *, Ayachit Shreyasa , Abhishek P. R. Nadigaa , Seema Mehdia , Suman Pathakb and Sunil S. Chiplunkarc

IN SILICO ANALYSIS OF PHYTOCHEMICALS FROM VARIOUS PLANT SOURCES AS DRUG CANDIDATES AGAINST LIFE-THREATENING DISEASES

PAGE 89-101

Epigenetic changes and glycation play a significant role in the progression of life-threatening diseases like diabetes, cancer, cardiovascular diseases (CVDs), neurodegenarative diseases (ND) and others. Exploring natural sources for overall therapeutic effect can be a beneficial approach for tre...

Suruchi Jamkhedkara *, Anakha P. Naira , Kishori R. Hirodea , Mayuri D. Chavana , Mili P. Jaina and Prachi P. Majumdara

Short Communications

METHOD DEVELOPMENT AND VALIDATION OF FLURBIPROFEN SODIUM BY USING UPLC

PAGE 102-104

A simple, precise, and accurate ultra-performance liquid chromatography was developed for flurbiprofen sodium on Acquity BEHC18, (50 x 2.1 mm, 1.7 µm) using acetonitrile: water: glacial acetic acid as the mobile phase. The flow rate was 0.2 mL min-1 and effluent was monitored at 254 nm. The rete...

Shraddha V. Tathea * and Shivangi Guptab

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