Table of Contents

September  2022

  • Volume 59
  • Issue 9
  • Page Nos. 104

Guest Editorial

THE IMPACT OF REGULATIONS ON RESEARCH AND DEVELOPMENT OF NOVEL NUTRACEUTICAL PRODUCTS

PAGE 5-6

Dear Reader,

‘Colonial mindset’ is a deeply embedded mindset that feels like the only norm to the perpetrators! Being victimized by the Food and Safety Standards Association of India (FSSAI) invoked ‘Product Approval System’ (PAS), albeit – and thankfully temporarily, is an akin...

Dr R K Sanghavi

# Consultant - NeuroMarketing & TechnoRegulatory (Pharma & Nutra)

# Chairman – Nutraceutical Committee (IDMA)

Review Article

A CONCISE LITERATURE REVIEW ON STUDY OF MICROSPONGES FROM ANCIENT TO RECENT

PAGE 7-15

Polymeric microspheres enclosing an extremely porous surface are termed as microsponges. Microsponges are drug loaded microporous beads having 10-25 micron diameter. These may augment stability, ease side effects and amend drug release. Microsponge systems have capability to capture ample drug su...

Suchitra Nishala , Parmita Phaugata , Renu Tushira and Manish Dhalla*

CROHN’S DISEASE: A REVIEW ON EPIDEMIOLOGY, DIAGNOSIS AND THERAPEUTIC MANAGEMENT

PAGE 16-28

Crohn’s disease (CD) is a kind of inflammatory bowel disease (IBD) characterized by the chronic transmural inflammatory state of gastrointestinal tract that typically affects ileum, colon, and perineum. Although the precise etiology is unknown, the major risk aspects concerned with CD consist o...

Mohammad Mukima,b*, Mohit Chaturvedia , Rakesh Patela , Supriya Royc , Pratishtha Sharmad, Varunesh Chaturvedie , Saloni Goyale and Mohsina F. Patewkarf

Original Research Articles

WOUND HEALING, ANTIMICROBIAL AND ANTIOXIDANT POTENTIALS OF CEDRUS DEODARA LOUD. AND PINUS ROXBURGHII SARG.

PAGE 29-40

The aim of this study was to investigate wound healing, antimicrobial and antioxidant activities of Cedrus deodara and Pinus roxburghii. The chloroform extract of C. deodara was found to possess significant wound healing potential, as evident from the rate of wound contraction, epithelization and...

Amrendra K. Chaudharya *, Vandana Singhb, Shamim Ahmadc and Avijit Mazumderd

SYNTHESIS AND MOLECULAR DOCKING STUDIES ON BIOLOGICALLY ACTIVE PYRAZOLE TERMINATED IMINO NAPHTHYL DERIVATIVES

PAGE 41-49

In this present study, a series of pyrazole terminated imino naphthyl derivatives were synthesized by the condensation reaction between 1,3 - diphenyl pyrazol-4-carboxaldehyde with substituted aromatic amines. The compounds were analyzed for their in vitro antimicrobial activities against some ba...

Sandhya P. Veetilab* and Haridas R. Karickalb

MESOPOROUS SILICA NANOPARTICLES OF HESPERIDIN: SYNTHESIS AND IN VITRO CHARACTERIZATION

PAGE 50-55

This work represents an attempt to synthesize mesoporous silica nanoparticles and to take advantage of its surface area, pore size and pore volume for delivery of drug. In this work hesperidin, a bioflavonoid obtained from citrus fruit, was successfully loaded on silica nanoparticles by solvent i...

Moreshwar P. Patila *, Snehal D. Boradea , Deepak S. Bhamberea and Sanjay J. Kshirsagara

STUDIES IN DEVELOPMENT, VALIDATION AND APPLICATION OF ANALYTICAL RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF GLIPIZIDE FROM ITS BULK AND FORMULATION

PAGE 56-65

A RP-HPLC method has been developed for the estimation of glipizide (GLP). The proposed method is based on the separation of the drug in reversed-phase mode using BDS HYPERSIL C18 (4.6 mmø×250 mm) analytical column, mobile phase methanol:water 70:30 V/V, at the flow rate of 1.0 mL min-1 and det...

Abhay R. Shirodea *, Pravada N. Patila , Umesh R. Dhasa and Vilasrao J. Kadama

VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF MODAFINIL IN PHARMACEUTICAL FORMULATION

PAGE 66-73

Two simple, sensitive, and fast visible spectrophotometric techniques for quantifying modafinil in marketed dosage form have been proposed. The method A was focussed on the complexation involving charge transfer with picric acid to give pale yellow colored chromogen which shows absorption maxima ...

Hemant Kumar T.a *, Srinivasa Rao Y.a , Vara Prasad Rao K.a and Vasudha D.a

APPLICATION OF ICH Q14 CONCEPT FOR CHEMOMETRICS-ASSISTED DEVELOPMENT OF SPECTROPHOTOMETRIC METHODS FOR ESTIMATING PIMAVANSERIN IN TABLETS

PAGE 74-81

In the present study, a novel analytical procedure development concept is utilized along with a chemometrics approach. Two sensitive UV spectrophotometric methods were developed for quantifying a new antipsychotic agent, pimavanserin tartarate, in tablets. The scanning speed and sampling interval...

Sagar S. Pandaa *, Ravi Kumar V. V. Beraa and Biswajit Sahua

A SIMPLE AND VALIDATED HP-TLC METHOD FOR SIMULTANEOUS ANALYSIS OF ETHNO-MEDICINE GALLIC ACID AND EUGENOL

PAGE 82-87

A new method has been developed and validated for the simultaneous estimation of gallic acid and eugenol for the poly-herbal formulation. The HP-TLC (High Performance Thin Layer Chromatography) method was developed using pre-coated silica gel 60 F254 on aluminum plate and the solvent s...

Amruta R. Balekundria *, Vinodh Kumar S. Mannura and Mahendra K. Chouhanb

Short Communications

SCREENING OF MOST EFFECTIVE VARIABLES FOR DEVELOPMENT OF TELMISARTAN LIPOSOMES BY TAGUCHI DESIGN

PAGE 88-90

The aim of this study was the selection of the most effective variable for the formulation of telmisartan liposomes. Liposomes were prepared by dry film deposition method using a Rota evaporator. The effects of formulation and processing variables on different response variables were studied usin...

Hiral M. Manania,b* and Lalit Lata Jhac

UV-SPECTROPHOTOMETRIC DETERMINATION OF PARTITION COEFFICIENT (LOG P) OF OLEANOLIC ACID AND ITS COMPARISON WITH SOFTWARE PREDICTED VALUES

PAGE 91-93

Oleanolic acid is reported to have various pharmacological activities of therapeutic interest. In order to use it in modern therapy, it is necessary to understand about its drug designing parameters. The current study deals with the determination of partition coefficient (log p) of oleanolic acid...

Nilesh B. Banarasea,b* and Chanchal D. Kaura

RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PHARMACEUTICAL TABLET DOSAGE FORM CONTAINING AMBRISENTAN

PAGE 94-97

The objective of the current study was to develop a simple, precise and accurate RP-HPLC assay method and its validation for determination of ambrisentan in pharmaceutical tablet dosage form. Gradient RP-HPLC separation was achieved on an analytical Primsil C18 R column (250 mm × 4.6 mm; 5 µm p...

Rupali M. Petkara , Subhash V. Deshmaneb*, Snehal S. Deshmaneb and Shirish P. Jainc

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