Table of Contents

April  2022

  • Volume 59
  • Issue 4
  • Page Nos. 68

Editorial

IPR POLICY VS REGULATORY POLICY

PAGE 5-6

Dear Reader,

Let us get ready to face the global healthcare challenges with positive attributes and approaches to regulatory pathways.

Resisting evergreening and extreme imbalances in Intellectual Property and patient practices may be a good option to continue from the Uruguay Rou...

Dr. Gopakumar G. Nair

Editor

Indian Drugs

Review Article

LAWSONE FROM LAWSONIA INERMIS: ISOLATION AND PHARMACOLOGICAL ACTIVITIES

PAGE 7-17

Lawsone, also known as hennotannic acid, is the natural pigment obtained from henna. Lawsone is chemically 2-hydroxy-1,4-naphthoquinone. The presence of the hydroxyl group is the major determinant of its biological activity. Lawsone is extracted from the henna plant by solvent extraction using no...

Shincy M. Francisa , Elizabeth N. Xaviera * and Lins M. Joyb

Original Research Articles

2D QSAR MODEL BASED ON 1,2-DISUBSTITUTED BENZIMIDAZOLES IMPDH INHIBITORS

PAGE 18-23

Quantitative structure activity relationship (QSAR) analysis of 1, 2-disubstituted benzimidazoles IMPDH inhibitors was studied for their antibacterial activity. The 2D QSAR model was developed using molecular suite (VLife MDS 4.3.1) on a set of 38 molecules. Multiple Linear Regression (MLR) was i...

Maithili S. Poklea , Rashmi D. Singha and Madhura P. Vaidyaa *

NATURAL BIODEGRADABLE CIPROFLOXACIN MICROSPHERES: OPTIMIZATION STUDY BY FACTORIAL DESIGN

PAGE 24-33

Oral drug delivery is the most popular method of control and release of therapeutic agents for the management of diseases. The colon specific drug delivery systems are considered to attain targeted drug delivery to the large intestine specifically at colon. They provide local delivery for the tre...

Neha Jaina , Mohan L. Koria , Umesh K. Jainb and Abhishek K. Jainb*

GREEN SYNTHESIS OF MANGANESE OXIDE NANOPARTICLES USING KIGELIA AFRICANA (LAM.) BENTH. AQUEOUS ROOT EXTRACT AND INFLUENCE ON CHICKPEA (CICER ARIETINUM LINN.) SEED GERMINATION AND PLANT GROWTH

PAGE 34-39

Use of different seed priming treatments improves seed germination and thus increases plant growth and yield potential. Eco-friendly, cost-effective, simple, and effective seed treatments need to be developed for a high-consuming crop like chickpea (Cice rarietinum Lin.). In the present ...

Usha Rani N.a *, Pavani P.a and Prasad Rao P. T. S. R. K.b

DEVELOPMENT AND VALIDATION OF NOVEL STABILITY INDICATING RP-HPLC METHOD FOR QUANTIFICATION OF ALIMEMAZINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

PAGE 40-45

Specific stability-indicating reversed-phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the quantification of alimemazine in bulk drug and pharmaceutical dosage forms. Chromatographic separation was done on C 18 column (250 mm X 4.6 mm X 5 µm) us...

Anil Kumar S. Manchia *, Satish Kumar Shetty A.a and Satyanarayan D. Nayakb

NOVEL ECOFRIENDLY TECHNIQUE FOR SPECTROPHOTOMETRIC ANALYSIS OF DICLOFENAC SODIUM TABLETS USING MELTED N, N- DIMETHYLUREA AS SOLID SOLVENT

PAGE 46-50

Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include alcohol, chloroform, benzene, methylene chloride, dimethyl formamide, acetonitrile, toluene, acetone and hexane. The main drawbacks of organic solvents are high value, toxicity and pollution. Hence, it...

Pranali Dhuma , Minakshi Nehetea * and Rajesh Maheshwarib

IMMUNOMODULATORY ACTIVITY OF PORTULACA QUADRIFIDA IN MALE ALBINO WISTAR RATS

PAGE 51-56

Immunomodulators are substances that stimulate, restore, suppress, or help to produce (adjuvant) or increase the desired immune response. Portulaca quadrifida is a traditional plant in the Ayurvedic system of medicine which has been reported to show a variety of therapeutic activities. This study...

Saumil A. Vaidyaa and Swati R. Dhandea *

Short Communications

STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF ELIGLUSTAT TARTRATE

PAGE 57-59

For determination of eliglustat tartrate, a new, specific, simple, accurate (recovery) and precise stabilityindicating HPLC method has been developed and validated according to ICH Q2(R1) guidelines. The HPLC method was developed using acetonitrile: 0.1 % orthophosphoric acid 40:60 (V/V) as mobil...

Minal Ghantea *, Pooja Siddheshwarea , Vidhya Bhusaria, Sanjay Sawantb, Vasundhara Sawantb and Preeti Kulkarnic

EFFECT OF HYDROPHILIC POLYMER ON DESIGN EXPERT ASSISTED ORO-DISPERSIBLE STRIP (ODS) OF ISOSORBIDE MONONITRATE

PAGE 60-64

Oral conventional formulations like tablets, capsules and liquids have many limitations. Due to this and patient incompliance, there is a need to develop new formulations with better efficiency and stability. The aim of the present study was to develop and optimize fast dissolving Oro-dispersible...

Prakash N. Kendrea *, Akash R. Aherb, Somnath K. Vibhutea , Ajinkya K. Potea , Subhash V. Deshmanea and Shirish P. Jainc

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