Table of Contents

December  2022

  • Volume 59
  • Issue 12
  • Page Nos. 100

Editorial

ORAL REHYDRATION THERAPY

PAGE 5-6

Dear Reader,

Cholera epidemics have wiped out clans, communities, and large chunks of populations whenever they have raged across the globe. Of the seven large epidemics over the last two hundred years, lasting from seven to twenty-four years, Bengal has bome the brunt of its four times. ...

Dr. Nagaraj Rao

Associate Editor

Indian Drugs

Review Article

RECENT ADVANCES IN CAPILLARY ELECTROPHORESIS

PAGE 7-20

Capillary electrophoresis is a rapid, flexible and effective separation technique with minimum requirement of sample and chemicals. This article focuses on recent advances in capillary electrophoresis, covering various preconcentration techniques, methods, injection techniques, detection techniqu...

Charu P. Pandyaa * and Sadhana J. Rajputb

Original Research Articles

DESIGN, SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME NEW COUMARIN FUSED OXAZOLE DERIVATIVES

PAGE 21-30

A new series of dihydro-1, 2-oxazole coumarin derivatives (SR1-SR10) was prepared using a multi-step reaction. The syntheses of intermediates coumarinyl chalcones and final compounds were characterized by IR, Mass, and 1 H NMR spectra. The final compound’s SR1-SR10 binding mode and its inhibito...

Pankaj Kumara , Rishi P. Kapoorc , Abhishek Kumara *, Soundarya M. Raia and Prashant Nayakb

DESIGN AND OPTIMIZATION OF SIMVASTATIN LOADED SOLID LIPID NANOPARTICLES USING FULL FACTORIAL DESIGN

PAGE 31-39

In the present study solid lipid nanoparticles (SLNs) of simvastatin were formulated using glyceryl monostearate and stearic acid in the ratio of 1:1 by applying 32 factorial design. The SLNs were optimized to check the effect of melted lipid and surfactant concentration on particle size and entr...

Jai B. Sharmaa , Vishal Sharmaa , Manish Kumara and Shailendra Bhattb*

DEVELOPMENT OF MUTRALA KASHAYA - A NOVEL AYURVEDIC DECOCTION

PAGE 40-45

Renal calculi, one of the most common social problems caused by incorrect urine elimination. By the process of excretion of urine in excess quantity, Mutrala drugs help in the removal of renal stones through the urine or lessen their size. A novel decoction was prepared by ingredients having diur...

Kishore K. Ka , Rudramma R. Hirematha *, Mahadev B. Gundakallea , Prasad B. S.a and Skandan S.a

ACCELERATED STABILITY STUDIES OF WEDELOLACTONE IN A POLYHERBAL FORMULATION BY RP-HPLC

PAGE 46-49

Stability of the marker compound is important so as to ensure claimed bioactivity and it also helps to predict the shelf life of the drug/formulation with respect to the active constituents. Eclipta alba (Asteraceae) is an important ingredient in various polyherbal/ayurvedic formulations. Wedelol...

Vandana Jaina *, Rashmi Patila and Kirti S. Laddhab

REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC) METHOD DEVELOPMENT AND VALIDATION OF SAXAGLIPTIN FROM HUMAN URINE

PAGE 50-54

Reversed phase high performance liquid chromatography (RP-HPLC) method for the quantitative determination of saxagliptin (SXG) in human urine was developed and validated to support clinical studies. Chromatographic separation was achieved on an Inertsil® column (250 mm x 4.6 mm, 5 µm). Isocrati...

Amol S. Bansodea *, Shubhangee S. Gaikwada and Vishal D. Shelkeb

DEVELOPMENT AND VALIDATION OF A NOVEL STABILITY INDICATING REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR RELATED SUBSTANCES AND ASSAY ANALYSIS OF MOLNUPIRAVIR DRUG SUBSTANCE AND DRUG PRODUCT

PAGE 55-69

Molnupiravir, a broad-spectrum antiviral is an isopropyl ester prodrug of β-D-N4-hydroxycytidine. Molnupiravir targets RNA-dependent RNA-polymerase enzyme of the viruses. A new stability-indicating HPLC-method was developed to determine related substances and assay of molnupiravir. Separation wa...

Manoj A. Mangukiyaa,b, Pritam V. Bagweb, Aman. A. Desaia and Shreerang V. Joshib*

PRUNETIN ATTENUATES D-GALACTOSE-INDUCED BRAIN AGING VIA INHIBITING AMYLOID-β AND TAU PROTEIN AGGREGATION

PAGE 70-78

The objective of this investigation was to assess the effect of prunetin in D-galactose-induced brain aging in rats and its regulating mechanisms. D-galactose (200 mg kg-1 body wt.) was given orally daily for 45 days to accelerate aging, and prunetin (10, 20,40, and 80 µg kg-1 body wt. respectiv...

Swathi Nallaa,b and Suhasini Gantab*

Short Communications

SPECTROPHOTOMETRIC DETERMINATION OF ANTINEOPLASTIC DRUG GEFITINIB IN TABLET DOSAGE FORM USING INORGANIC SOLVENT

PAGE 79-81

In the present research work, a simple, accurate and precise spectrophotometric method has been developed for the determination of gefitinib in bulk and its tablets dosage form. Gefitinib was dissolved in 0.1 N hydrochloric acid and absorbance was measured at 252.0 nm. The calibration curve obeye...

Shailesh K. Koradiaa *, Dhwani R. Patelb, Prachi A. Ranab, Binny A. Rudanib and Unnati S. Chaudhari

FORMULATION AND EVALUATION OF POLYHERBAL HAIR OIL FOR GENERAL PURPOSE

PAGE 82-84

The present era is witnessing a renaissance of herbal products due to the credence of having no or minimal adverse effects allied with them. The present lifestyle (stress, anxiety, lack of nutritious diet, lethargy, unusual sleep pattern etc.) as well as pollution triggers the hair loss not only ...

Akanksha Dwivedia , Rakhi Khabiyaa *, Pawan Mulania, Manali Parkhia , Vikas K. Jaina and Gajanan N. Darwhekara

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