Articles Accepted

Investigation of the hepatoprotective potentials of fractions and phytosomonal complexes of Telfairia occidentalis Hook F leaf extracts on alcohol-induced hepatoxicity in rat models
by Mr. Romanus C. Omeh, 23 Jul 2023
Co-Author(s): Kenneth Obinna Okolo,Mercy Ebere Ugwueze,Chukwuemeka Christian Mbah,Anthony Atamma,Josephat Ogbonna,Mumuni Audu Momoh,Lydia Onyinyechi Ugorji

The aim of this work was to evaluate the hepatoprotective potentials of fractions and phytosomonal complexes of Telfairia. occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomonal complexes of ethanol extract fractions were prepared by the thin film hydration technique. Hepatoprotective activities were evaluated by biochemical assays and histopathological examination of liver sections. Intoxication of animals with pure ethanol significantly (p 0.05) elevated their liver enzyme titres whereas co-administration with various extracts and phytosomonal complexes reversed the increases. Histopathological findings revealed liver tissue protective effects of the extracts with the phytosomal complexes exhibiting greater effects (p 0.05). Significant differences at p ≤ 0.05 were observed in the liver indices of animals treated with co-administered ethanol and extract fractions or phytosomee complexes versus the positive control group. T. occidentalis leaf extract formulated as phytosomes, therefore, has good potential of enhancing the hepatoprotective activities of the extract.

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