Articles Accepted

IN VITRO ANTIOBESITY ACTIVITY OF SOME PLANTS THROUGH A MODIFIED PANCREATIC LIPASE INHIBITION ASSAY
by Dr. AJAY SEMALTY, 03 Jul 2023
Co-Author(s): . Radheshyam,Bhawna Basnal,Mona Semalty,Ajay Semalty,Priyanka Gauniya

The objective of the present study was to evaluate the antiobesity potential of various plant (leaves or seed) extracts through a modified in vitro lipase inhibitory activity assay. Dimethyl Sulphoxide (DMSO, negative control or solvent) extracts as cold infusion of leaves and seeds of some plants were studied for lipase inhibitory potential using porcine pancreatic lipase enzyme, p- nitro phenyl acetate and orlistat (as positive control or standard inhibitor). Among the leaves, the Urtica dioica showed the best pancreatic lipase inhibition activity (52.0%). On the other hand, among the seeds, Trachyspermum ammi showed the highest percent lipase inhibition (91.68 %). Among 6 leaves’ and 7 seeds’ extract, it was evident that the seeds showed better pancreatic lipase inhibition activity over the leaves under the study. The lipase inhibition was found to be in the range of 34.43 to 91.68 % for the plants under study. DMSO extract of the plants under the study showed significant pancreatic lipase inhibitory activity indicating strong antiobesity activity. Therefore, the plants can be further investigated for the identification and isolation of chief bioactive constituents for developing the lead molecules for obesity treatment.

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