Articles Accepted

Safety assessment of Suvarna Bhasma, an ayurvedic gold medication, in Wistar rats.
by Dr. Mahalaxmi Mohan, 19 May 2023
Co-Author(s): Abhay N. Kulkarni,Mahalaxmi Mohan,Pankaj s. Patil,Mayuri D. wagh,Shishir P. Pande,Rajshree A. Kulkarni

Suvarna Bhasma (SB) contains gold and lead which are highly potent metals and are toxic in their crude form. The present study aims to evaluate the safety profile of the drug. The test drug was administered orally once a day for 90 consecutive days at three dose levels (10.23mg/kg, 40.92mg/kg, and 102.3mg/kg body weight). Clinical observations, feed and water consumption, and body weight changes were noted during the study period. On the 91st day, hematological, biochemical, and histopathological changes were studied. There was a significant decrease in body weight of rats at a low dose (10.23mg/kg) at fourth week, which could not be correlated with feed and water consumption findings. Thus, change was not considered as a treatment-related effect. Suvarna Bhasma showed no evident toxic effect in Wistar rats during the repeated dose subchronic toxicity study for 90 days, even at 10 times of the therapeutic dose (102.3 mg/kg).

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