Articles Accepted

EVALUATION OF IN VITRO CYTOTOXIC POTENTIAL OF DIFFERENT CARMUSTINE FORMULATIONS AGAINST U87MG HUMAN GLIOBLASTOMA CELL LINES
by Mr. Audumbar Mali, 02 Nov 2023
Co-Author(s): Anil Subhash Bhanwase

Glioblastoma (GBM) is the frequent as well as violent type of brain tumor. In this research work, different carmustine formulations were prepared and screened for their cytotoxic activity against U87MG glioblastoma and normal human fibroblast L929 cell lines. The flexible liposomes embedded in situ thermoreversible intranasal gel showed maximum % of growth inhibition against U87MG glioblastoma cell lines and in situ thermoreversible intranasal gel showed lowest percentage of growth inhibition against U87MG glioblastoma cell lines. Flexible liposomes embedded in situ thermoreversible intranasal gel is observed to be safe and biocompatible against normal human fibroblast L929 cell lines. In cellular uptake study, U87MG cell lines treated with flexible liposomes embedded in situ thermoreversible intranasal gel emitted stronger and higher intensity fluorescence. It seems presence of flexible liposomes embedded in situ thermoreversible nasal gel inside the tumor cells and would be the best carmustine delivery approach for the management of GBM.

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December 2023
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