Articles Accepted

OXIDATIVE DEGRADATION OF TAVABOROLE: DETERMINATION BY DERIVATIVE UV SPECTROPHOTOMETRY
by Dr. Mrinalini Chintamani Damle, 06 Sep 2021
Co-Author(s): Mayuri H Suryawanshi

The aim of present work was to investigatedegradation behavior of Tavaborole, upon exposure tooxidative conditionsusing first order derivative UV spectrophotometric method. We provide simple and fast analytical method that can be used as quality control tool for the determination of Tavaborole. The method was based on oxidative studies over a period of time.The order of oxidative degradation reaction was calculated by using the log of recovered concentration obtained from the oxidative degradation study. The reaction was first order kinetics.The method was validated according to ICH guidelines. The linear response was found inthe concentration range of 5-25μg/mL at 271 nm. The % relative standard deviation (RSD) for precision studies of Intraday and Interday was 2%.

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November 2022
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