Amlodipine is a BCS Class I drug with high solubility and high permeability. It has a long half-life of 30-50 hours. It is a suitable model drug for formulating as orodispersive tablets as the oro-dispersive tablets can release the drug immediately. Thus, formulation of amlodipine into oro-dispersible tablets will help in improved delivery of the drug at a faster rate. To achieve this, the oro-dispersive tablets were prepared by sublimation technique and the concentration of the sublimating agents was optimized by Central Composite Design. Based on the results, it was concluded that Camphor and Thymol when used at optimum concentrations can be used in the formulation of Oro Dispersive Tablets, the drug delivery systems for drugs with long half life. They can be used as efficient means of formulation to enhance palatability also for model drugs like Amlodipine.
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