Articles Accepted

Pharmacodynamic Evaluation of dietary supplementation of Averrhoa carambola fruit extract against Lead acetate-induced hepatotoxicity in rats
by Dr. Neetu Sachan, 04 Jun 2021
Co-Author(s): Ranjeet Singh,Shiv Dev Singh,Phool Chandra

Lead is a toxicant present and it may induce a wide range of social, biochemical and physiological belongings in humans. This study is undertaken to evaluate the pharmacodynamic effects of dietary supplementation of Averrhoa carambola fruit extract (ACF) against lead acetate-induced hepatotoxicity in rats. Six groups of rats were used in this study, Control, Lead acetate (20 mg/kg, ip), Lead acetate (20 mg/kg, ip)+ 200 mg/kg Silymarin orally (reference drug), Lead acetate + 100 mg/kg ACF orally, Lead acetate + 150 mg/kg ACF orally and Lead acetate + 200 mg/kg ACF extract orally. All experimental groups except control received the lead acetate by intraperitoneal route for 5 days and normal saline or Silymarin or ACF by oral route employing orogastric cannula for seven days. Lead intoxication leads to a significant increase in ALT, AST activities, malondialdehyde (MDA), and a significant decline of liver homogenate reduced glutathione (GSH) level and superoxide dismutase (SOD) activity. Different doses of ACF supplement, as well as Silymarin, lead to improving biochemical parameters of serum and liver and prohibited the lead acetate-induced significant changes in plasma and antioxidant status of the liver. ACF or Silymarin supplement exhibited more antioxidant activity. Conclusively, the results of the present work revealed that the treatment of lead-intoxicated rats with Averrhoa carambola fruit extract supplement revealed a significant increase in GSH level, CAT, SOD activity, decrease in TBARS levels as compared to lead-intoxicated rats indicating its antioxidant activity.

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