Articles Accepted

The current research aimed to develop and test a system of vesicular drug carrier for topical drug administration of Vitex negundo Linn in order to provide sustained drug delivery. The ethosomes of Vitex negundo Linn were produced using thin-film hydration with soy lecithin, and their in- vitro drug release profiles, size, drug content, and other characteristics were examined. To attain the desired results for drug release and entrapment effectiveness, the composition of lecithin and ethanol was changed to form ethosomes. The ethosomal size of vesicle of the optimised formulation batch was measured to be 13.47 d.nm with -3.97 mV as zeta potential. The percent drug release of ethosomal gel was 83.24%, and the percent entrapment efficiency was 89.40%.The formation of spherically shaped vesicles was revealed by optical and scanning electron microscopy observations. As increasing ethanol concentration the formulation’s in-vitro profile for drug release increases and lipid concentration getting reduced.