Articles Accepted

DESIGN AND OPTIMIZATION OF OCULAR INSERTS FOR PROLONGED DELIVERY OF CIPROFLOXACIN HYDROCHLORIDE WITH CORTICOSTEROID.
by Dr. Swati, 02 Mar 2023
Co-Author(s): Leena Ajay Sawaikar,Anushka Ajay Savaikar

Ocular conjunctivitis is one of the main causes of red eye syndrome and so is the Ocular drug delivery, which is one of the most challenging and fascinating tasks faced by the Pharmaceutical Researchers. The challenges to the formulators are to circumvent the protective barriers of the eye without causing permanent tissue damage, maintain a stable therapeutic level at the site of action for a prolonged period of time. The present work focuses on the treatment of ocular conjunctivitis by using combined mechanisms: 1. Fluroquinolone antibiotics to provide sustained release of drug from ocular inserts. 2. Use of corticosteroid to provide anti-inflammatory effect providing comfort to the patient. 3. Selected polymers were Carbopol, PEG to enhave the rheological properties of the film and release patterns of active. Quinolone Antibiotics like Ciprofloxacin 2) Anti-inflammatory agents like Dexamethasone 3) Polymer: HPMC, MC, EUDRAGIT RS 100, EUDRAGIT RL 100, or any other polymers and 4) Excipients: Cholesterol, Span 60, Tween 60, other available excipients were procured from pharmaceutical companies as gift samples. Different combinations of antibiotics and anti-inflammatory agents were prepared by Solvent Cast Method wherein the polymer was dissolved in distilled water. A plasticizer was added to this solution with continuous stirring followed by addition of weighed amount of drug to get a uniform dispersion. After proper mixing the casting solution were poured in the clean glass petri dish and covered with an inverted funnel to allow slow and uniform evaporation at room temperature for 48 hours. The dried films were cut by cork borer into circular pieces of definite size containing drug and evaluated for different parameters and sustained drug release [2]. On the basis of in-vitro, in-vivo correlation stability studies the formulation (antibiotic + anti-inflammatory agent) promising the best once a day sustained release of the drug will be chosen. Key words: - Quinolone antibiotics, anti-inflammatory agents, conjunctivitis, occuserts, in-vitro release pattern, physico-chemical evaluation

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