Articles Accepted

Febuxostat is a poor soluble drug used in the management of hyperuricemia and gout. The present study aims at increasing the solubility of febuxostat by solid dispersion technique us-ing various polymers (Beta cyclodextrin, Soluplus®, HPMC E5, and Kolliphor P 407) in var-ious drug: carrier ratio’s using the solvent evaporation method. Solid dispersions were evalu-ated for physical appearance, percentage yield, drug content, saturation solubility studies and dissolution studies. Saturation solubility studies revealed that there was an increase in solubil-ity of the solid dispersion compared to the pure drug. In-vitro release profiles revealed that formulation SD20, having drug: Kolliphor P 407 (1:9 ratio) exhibited highest dissolution rate. The powder X-ray diffraction study and scanning electron microscopy studies revealed that crystalline drug was converted to an amorphous form in solid dispersion. The study demon-strated that preparation of solid dispersion is a highly effective technique to increase solubili-ty, dissolution and bioavailability of a poorly soluble BCS class II drug febuxostat.