In the present study, an analytical UV and HPLC methods were developed for the estimation of repaglinide from a tablet dosage form. UV method shows linearity in the range of 10-30 µg/ml with a relative coefficient of 0.9999. HPLC method shows linearity in the range of 10-30 µg/ml with a relative coefficient of 0.9985. Each method was validated for different validation parameter such as specificity, precision, accuracy, linearity, robustness, repeatability, limit of detection (LOD) and limit of quantification (LOQ). The result was found to be within the acceptance limits as per ICH guidelines. Developed method was compared with some reported methods by statistical analysis one way ANOVA (Analysis of Variance) test and it was found to be statistically significant.
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