Articles Accepted

Development of Mutralakashaya- A Novel Ayurveda Decoction
by Dr. Rudramma R Hiremath, 09 May 2018
Co-Author(s): Kishore K K,Prasad B S ,Skandan K Pnil

Background: Urine is one of the waste in body, which is to be eliminated in proper quantity. Among the disorders prevailing in society due to improper elimination of urine, renal calculi plays major role. By the process of excretion of urine in excess quantity Mutrala drugs helps in expelling the renal stones through urine or reduces its size. Mutrala is one of the property which is described by various Ayurvedic texts in the context of dravyas and yoga’s. As the name indicates Mutrala dravya (Diuretic) any drug that elevates the rate of urination and thus provides a means of forced diuresis. As boiled water is having basti shodhana property, also helps to increase urine output and can help in treating renal calculi. So polyherbal kashaya is selected as the dosage form for the study. Aim: To develop the new formulation Mutrala kashaya by using the drugs having diuretics and lithotropic properties. Materials and Methods: Mutrala Kashaya was prepared by Agnisamskara using course powder of Punarnava (Boerhavia diffusa Linn), Gokshura (Treibulus terrestris Linn), Pashanabeda (Bergenia ligulata Wall), Varuna (Crateva nurvala Buch- Ham), Dhanyaka (Coriandrum sativum Linn), Ushira (Vetivera zizanoids Linn), Kushmanda (Benincasa hispida Thunb) and Kulatha (Vigna unguiculata Linn). Polyherbal decoction (Kahsaya) was standardized by analytical and pharmaceutical parameters. The formulation was analysed by assessing physiochemical and phytochemical parameters followed by microbial limit test and plate counts of bacteria and fungi. Results All phyto and physio chemical values of all drug was under standard range of API. Mutrala kashaya is Light brown in color, pleasant odor; slight bitter in taste, temperature maintained is 31 - 107˚C for the preparation of kashaya. Total solid of Mutrala kashaya was 4.92%, pH was 4.5, specific gravity was 1.04, refractive index was 1.349, viscosity was 0.00125 mm2/ sec, HPTLC showed 16 Rf values. It has presence of reducing sugars (1.5%), fats, and oils along with cardiac and saponin glycosides. The drug was antimicrobial in nature and safe. Conclusion Mutrala kashaya can be developed by using herbal drugs having diuretic and lithotropic effect. It has showed effect in renal calculi based on various parameters. However, evaluation of mode of action and maximum efficacy of kashaya can be further evaluated by extraction of the principle acting components in various solvents.

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