Articles Accepted

DEVELOPMENT AND CHARACTERIZATION OF CANDESARTAN NANOCRYSTALS
by Dr. Venkatesh D P, 17 Jan 2017
Co-Author(s): Tripti Joshi,Roopa Karki,Divakar Goli,Sailaja Lakkori

Nanotechnology is a potential new direction in the pharmaceutical research. Candesartan is an antihypertensive agent belonging to Angiotensin II receptor blocker class. Candesartan is slightly soluble in water, available in crystalline form. Candesartan nanocrystals were prepared by nanoprecipitation method to increase the dissolution rate. Pluronic F-68 and PVP K-30 were used as stabilizers. X-Ray diffraction studies showed that the crystalline nature was restored. The particle size nanocrystals range between 151 to 499 nm. SEM studies revealed that nanocrystals were found to be cubic crystal in shape. Zeta potential showed moderate stability. Polydispersity index was found to be in the range of 0.127 to 0.246. In vitro drug diffusion study showed maximum drug release up to 95.62%. No significant difference was observed for In vitro drug diffusion study and drug content after intermediate stability studies. It was concluded that optimized formulation was ensured better stability, enhance the dissolution rate and reproducible.

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