Table of Contents

March  2024

  • Volume 61
  • Issue 3
  • Page Nos. 72

Guest Editorial

TIME TO THINK “BOTSIMILAR”

PAGE 5-6

Dear Reader,

Ever since the Dietary Supplement Health and Education Act (DSHEA) was notified in the US in 1994, discussion on botanicals for wellness continues. Botanicals to be used for providing wellness health benefits opened up a large market for consumer benefits. Nations like India ...

Dr. D B Anantha Narayana, PhD.

Editorial Advisory Board Member, Indian Drugs

Review Article

MICROBALLOONS: A PROMISING APPROACH FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM AND THEIR ADVANTAGES, LIMITATIONS, RECENT ADVANCEMENT IN DRUG DELIVERY SYSTEM, PATENTS AND FUTURE ASPECTS

PAGE 7-20

The key objective of the present review was to collect the latest literature on technological advancements towards microballoons as novelistic buoyant drug delivery systems. Microballoons are hollow microspheres with a potential approach for gastric retention, offering controlled release of the ...

Prashant Kumara *, Sumel Ashiqueb, Sugandha Varshneyc , Surya Nath Pandeya , Anjali Jaina and Anurag Vermaa

Original Research Articles

DEVELOPMENT AND EVALUATION OF METFORMIN TABLETS: EFFECT OF SUPERDISINTEGRANTS

PAGE 21-24

Metformin is an oral antihyperglycemic medication used to treat type 2 diabetes. BCS-III classification of medications includes metformin hydrochloride, which has a high solubility and a low permeability. This study’s objective was to develop wet granulated metformin hydrochloride tablets using...

Sankar Veintramuthua *, Giridharan Annamalaia and Ashma Shikkandara

ADVANCING PARKINSON’S DISEASE DETECTION WITH FLISA: A NOVEL APPROACH TARGETING MISFOLDED ALPHA-SYNUCLEIN

PAGE 25-29

A Fluorescence-Linked Immunosorbent Assay (FLISA) targeting β-cross-sheet α-synuclein protein, a crucial marker in Parkinson’s Disease (PD), was assessed using in vitro assay with a rotenone-induced PD cellular model. The study aimed to evaluate FLISA’s applicability with the inhouse develo...

Paramita Batabyala , Vishwas Sarangdharb, Ajay S. Sawnerc , Amruta V. Gadaded, Radni D. Deshpandee , Vikas D. Dighed and Sadhana Sathayee *

DIFFUSE REFLECTANCE INFRARED FOURIER TRANSFORM SPECTROSCOPIC METHOD FOR ESTIMATION OF NERATINIB IN PHARMACEUTICALS: APPLICATION TO ANALYTICAL QUALITY BY DESIGN AND GREENNESS ASSESSMENT

PAGE 30-39

In this research paper, we report an eco-friendly diffuse reflectance infrared fourier transform spectroscopic (DRIFTS) method for quantifying neratinib. The systematic method development was performed as per the recent analytical quality by design concept. The critical method variables such as r...

Sagar S. Pandaa *, Aman Kumara and Ravi K.V.V. Beraa

ESTIMATING THE RELEASE EFFECT ON BSC-I DRUG BY USING A COMBINATION OF METHYLCELLULOSE AND EUDRAGIT® S-100 POLYMERS TO FORMULATE MINI-FLOATING TABLETS

PAGE 40-45

The purpose of the current research was to prepare a delayed-release system of mini-tablets (gastroprokinetic drug). The model drug (itopride hydrochloride) was formulated with the combination of methylcellulose (free-flowing agent) and Eudragit® S-100 (enteric coating agent) for delayed release...

Kajal Nagpala , Fatimah Janb, Uditi Handaa *, Priyanka Kriplania , Rameshwar Dassa , Sheetal Sonia , Deepak K. Yadava , Kumar Guarvea and Sheetal Devic

PREPARATION AND EVALUATION OF COLON-SPECIFIC PROBIOTIC DELIVERY SYSTEM: SACCHAROMYCES BOULARDII

PAGE 46-55

Probiotics are beneficial microbes that have a beneficial effect on humans as well as animals. Despite their advantages, probiotics face viability challenges during storage and while passing through the upper gastrointestinal tract. This study was designed to develop an encapsulated system of Sac...

Seema B. Chauhana *, Ranjit Singha and Himani Bajaja

IN VIVO EVALUATION OF OPTIMIZED FORMULATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN BILAYERED TABLETS

PAGE 56-60

Combining dapagliflozin and saxagliptin presents a promising strategy for managing type 2 diabetes mellitus by leveraging their distinct, yet complementary, mechanisms of action. A novel bilayer tablet with a 5 mg sustained release layer of saxagliptin and a 10 mg immediate release layer of dapag...

Rajani Vetapalema,b*, Rajendra Y. Prasadc and Lakshmana A. Raob

Short Communications

DESIGN AND EVALUATION OF RIVAROXABAN EFFERVESCENT GRANULES

PAGE 61-64

The present investigation is concerned with the formulation and development of rivaroxaban (RN) effervescent granules using a dry granulation process. A 23 factorial design was employed using Design-Expert® software to develop an ideal formulation. Formulations were evaluated, and showed outstan...

Rama Rao Nadendlaa *, Sandeep Kannaa and Juluri Satyanarayanaa

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