Table of Contents

January  2013

  • Volume 50
  • Issue 1
  • Page Nos. 1-72

Review Article

Cryptic Causes and Mechanisms involved in Ageing

PAGE 5-22

Ageing is a natural process characterized by progressive deterioration of biological functions. Ageing causes both morphological as well as biochemical alterations in various body organs leading to deterioration of health. Proteins, enzymes and neurotransmitters are a...

Challabotla K.*, Banji D., Banji O.J.F. and Reddy Chilipi K..

Original Research Articles

High-Performance Thin Layer Chromatographic Method for the Simultaneous Quantitation of Lopinavir and Ritonavir in Tablet Formulation

PAGE 23-29

The present work describes a simple, accurate and precise HPTLC method for simultaneous quantitation of ritonavir (RVR) and lopinavir (LVR) in tablet formulation. Chromatographic separation of both drugs was performed on precoated aluminum plates, silica gel 60 F254 a...

Fegade J. D.*, Chawla N. D., Chaudhari R. Y. and Patil V. R.

Design, Development and Evaluation of Cationic Guar and Hydroxypropyl guar Based In Situ Gels for Ophthalmic Drug Delivery

PAGE 30-41

The poor bioavailability and therapeutic response exhibited by the conventional eye drops due to rapid corneal loss is overcome by the use of ion-activated gel forming systems that are instilled as drops;these undergo gelation in cul-de-sac mode. The present study des...

Dasankoppa F. S. and Swamy N.G.N*

Effect of Hydrophilic Polymers on Controlled Release Matrix Tablets of Acyclovir

PAGE 42-49

Acyclovir was formulated as oral controlled release matrix tablets using natural and synthetic polymers separately or in combinations. Tablets were prepared by direct compression method. The tablets were evaluated to thickness, weight variation test, drug content, har...

Ashok Kumar P.* and Damodar Kumar S.

Synthesis and Biological Evaluation of 2-Substituted Phenyl-1-(Substituted Piperazin-1-Yl) Methyl)-1H-Benzo[D]Imidazoles

PAGE 50-58

A series of biologically active benzimidazole derivatives (2a-2n) was synthesized by the reaction of o-phenylenediamine with the derivatives of benzoic acid in presence of 4N-HCl followed by the reaction with piperazine and formaldehyde to undergo Mannich reaction. Th...

Gupta S. K., Kumar N., and Pathak D.*

Short Notes

Development and Validation of Difference Spectroscopic Method for the Estimation of Tolperisone Hcl in Bulk and Pharmaceutical Dosage Form

PAGE 59-63

Difference spectroscopic method is based on the principle that tolperisone hydrochloride can exhibit two different absorption spectra in basic and acidic medium. A stock solution (1 mg/ml) was prepared with distilled water. Further dilution was made by using 0.1 N sod...

Gohil K.*, Shah B., Patel B., Patel P. and Patel N.

Analgesic and Anti-Inflammatory Activities of Ixora Coccinea Flower

PAGE 64-67

The present study was an endeavor to evaluate anti-inflammatory and analgesic activity of methanolic extract of Ixora coccinea flowers (ICF-ME). The in vivo anti-inflammatory was evaluated in rats by using carageenan-induced paw edema, as an acute an...

Aher A.N., Pal S. C. and Muke S. A.*

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