The research was designed to examine the litholytic properties of the fruit of Kigelia africana. The presence of a high concentration of larger molecules in a plant extract prevents the aggregation and development of crystals, comparable to the function of natural substances found in urine that inhibit crystal formation. The pharmacological assessment of Kigelia africana was conducted using turbidity technique and dissolution percentage. CaOx were artificially synthesized and enclosed inside a somewhat SPM in both procedures. The results were statistically evaluated and shown a considerable anti-urolithiasis activity (P0.001) when compared to both the control group and the standard group (Berberis vulgaris).