Articles Accepted

Role of Quality by design for the optimization of Push pull osmotic pump of S-Metoprolol Succinate
by Dr. Bhupendra G. Prajapati, 26 Nov 2021
Co-Author(s): Dipesh V. Patel,Dignesh Khunt

Present research was focus on the preparation and evaluation of push pull osmotic pump of. S-Metoprolol Succinate based on Quality by design (QbD) approaches. For preparation of push pull osmotic pump, pull layer of S-metoprolol Succinate was prepared using low molecular weight polyox by wet granulation. Push layer containing higher molecular weight polyox and sodium chloride as osmotic agent was prepared by wet granulation. Both layers were compressed to get bilayer tablets and these bilayer tablets were coated with cellulose acetate which act as semipermeable membrane and polyethylene glycol which act as pore former. Extended release coated tablets were laser drilled on drug layer side to allow delivery of drug. Formulation was optimized using center composite design (CCD). Effect of different drilled diameter on drug release was also evaluated. Formulation was optimized using center composite design (CCD). Results shows that with decreased concentration of sodium chloride and increase % of extended release coating decreases the drug release form tablets. Optimization study revealed that percentage weight gain, concentration of the sodium chloride and cellulose acetate to PEG ratio were significant formulation variable which affect the drug release profile. Push pull osmotic pump of S-Metoprolol Succinate was successfully developed using low molecular weight polyox in pull layer and higher molecular weight of polyox in push layer.

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