Articles Accepted

UV Spectroscopic Method Development and Validation for Estimation of Potent Antiviral Drug Favipiravir
by Dr. Sandip D Firke, 17 Jul 2021
Co-Author(s): Rupali Patil,Md Mojeeb Khan,Mohan Kalaskar,Atul Shirkhedkar

A novel, simple and accurate UV-Spectrophotometry method have been develop and validate for the analysis of favipiravir in bulk and tablet formulation. Favipiravir, also known as 6-Fluoro-3-hydroxypyrazine-2-carboxamide, is an antiviral medication. It is a modified pyrazine analogue. The quantitative determination of the drug was carried out using the zero order derivative values measured at 323 nm. Linearity plot was constructed and linearity was followed in the concentration range of 4-20 μg/ml with coefficient correlation (r²) 0.9997 for zero order spectrophotometry method. The LOD and LOQ were found to be 0.08 µg and 0.26 µg, respectively. All the proposed methods have been extensively validated as per ICH guidelines. Developed spectrophotometry methods in this study are simple, accurate, precise and sensitive for Favipiravir in bulk and Tablet formulation.

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August 2022
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