Articles Accepted

UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION OF FIRST DERIVATIVE METHOD FOR SIMULTANEOUS ESTIMATION OF PRAZIQUANTEL AND ABAMECTIN IN FINISHED DOSAGE FORM
by Mr. Brijesh Dasvani, 27 Jul 2020
Co-Author(s): Avani Khristi

In the present investigation, Methanol is solubilizing agent to solubilize poorly water-soluble drugs such as Praziquantel and Abamectin. UV Spectrophotometric method has been developed for simultaneous estimation of Praziquantel and Abamectin in bulk drug and in their combined Pharmaceutical dosage form by first order derivative. This method utilizes methanol as a common solvent and λmax of Praziquantel and Abamectin selected for analysis was found to be at 248 nm (at ZCP of Abamectin) and 274 nm (at ZCP of Praziquantel) respectively. Linearity was observed in the concentration range of 25-150 μg/ mL for Praziquantel (r2 = 0.9984) and 1-11 μg/mL for ABAM (r2 = 0.9986). The accuracy and precision were determined and found to comply with ICH guidelines. This method shows good reproducibility and recovery with % RSD in the desired range. Developed method was applied for marketed formulation. The results were found to be within acceptance criteria according to ICH guideline.

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